PhytophthoraV1, Main, Exploration, bibRecord, 000438

Novel Peptide-Based Inhibitors for Microtubule Polymerization in Phytophthora capsici.

Identifieur interne : 000438 ( Main/Exploration ); précédent : 000437; suivant : 000439

Novel Peptide-Based Inhibitors for Microtubule Polymerization in Phytophthora capsici.

Auteurs : Sang-Choon Lee [États-Unis] ; Sang-Heon Kim [Corée du Sud] ; Rachel A. Hoffmeister [États-Unis] ; Moon-Young Yoon [Corée du Sud] ; Sung-Kun Kim [États-Unis]

Source :

International journal of molecular sciences [ 1422-0067 ] ; 2019.

RBID : pubmed:31146360

Descripteurs français

KwdFr :
- Antifongiques (pharmacologie), Liaison aux protéines (MeSH), Microtubules (effets des médicaments et des substances chimiques), Microtubules (métabolisme), Modulateurs de la polymérisation de la tubuline (pharmacologie), Peptides (pharmacologie), Phytophthora (effets des médicaments et des substances chimiques), Phytophthora (métabolisme), Tubuline (effets des médicaments et des substances chimiques), Tubuline (métabolisme).
MESH :
- effets des médicaments et des substances chimiques : Microtubules, Phytophthora, Tubuline.
- métabolisme : Microtubules, Phytophthora, Tubuline.
- pharmacologie : Antifongiques, Modulateurs de la polymérisation de la tubuline, Peptides.
- Liaison aux protéines.

English descriptors

KwdEn :
- Antifungal Agents (pharmacology), Microtubules (drug effects), Microtubules (metabolism), Peptides (pharmacology), Phytophthora (drug effects), Phytophthora (metabolism), Protein Binding (MeSH), Tubulin (drug effects), Tubulin (metabolism), Tubulin Modulators (pharmacology).
MESH :
- chemical , drug effects : Tubulin.
- chemical , metabolism : Tubulin.
- chemical , pharmacology : Antifungal Agents, Peptides, Tubulin Modulators.
- drug effects : Microtubules, Phytophthora.
- metabolism : Microtubules, Phytophthora.
- Protein Binding.

Abstract

The plant disease Phytophthora blight, caused by the oomycete pathogen Phytophthora capsici, is responsible for major economic losses in pepper production. Microtubules have been an attractive target for many antifungal agents as they are involved in key cellular events such as cell proliferation, signaling, and migration in eukaryotic cells. In order to design a novel biocompatible inhibitor, we screened and identified inhibitory peptides against alpha- and beta-tubulin of P. capsici using a phage display method. The identified peptides displayed a higher binding affinity (nanomolar range) and improved specificity toward P. capsici alpha- and beta-tubulin in comparison to Homo sapiens tubulin as evaluated by fluorometric analysis. One peptide demonstrated the high inhibitory effect on microtubule formation with a nanomolar range of IC₅₀ values, which were much lower than a well-known chemical inhibitor-benomyl (IC₅₀ = 500 µM). Based on these results, this peptide can be employed to further develop promising candidates for novel antifungal agents against Phytophthora blight.

DOI: 10.3390/ijms20112641
PubMed: 31146360
PubMed Central: PMC6600545

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000464
to stream Main, to step Curation: 000464

Le document en format XML

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<front><div type="abstract" xml:lang="en">The plant disease Phytophthora blight, caused by the oomycete pathogen <i>Phytophthora capsici</i>
, is responsible for major economic losses in pepper production. Microtubules have been an attractive target for many antifungal agents as they are involved in key cellular events such as cell proliferation, signaling, and migration in eukaryotic cells. In order to design a novel biocompatible inhibitor, we screened and identified inhibitory peptides against alpha- and beta-tubulin of <i>P. capsici</i>
 using a phage display method. The identified peptides displayed a higher binding affinity (nanomolar range) and improved specificity toward <i>P. capsici</i>
 alpha- and beta-tubulin in comparison to <i>Homo sapiens</i>
 tubulin as evaluated by fluorometric analysis. One peptide demonstrated the high inhibitory effect on microtubule formation with a nanomolar range of IC<sub>50</sub>
 values, which were much lower than a well-known chemical inhibitor-benomyl (IC<sub>50</sub>
 = 500 µM). Based on these results, this peptide can be employed to further develop promising candidates for novel antifungal agents against Phytophthora blight.</div>
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 using a phage display method. The identified peptides displayed a higher binding affinity (nanomolar range) and improved specificity toward <i>P. capsici</i>
 alpha- and beta-tubulin in comparison to <i>Homo sapiens</i>
 tubulin as evaluated by fluorometric analysis. One peptide demonstrated the high inhibitory effect on microtubule formation with a nanomolar range of IC<sub>50</sub>
 values, which were much lower than a well-known chemical inhibitor-benomyl (IC<sub>50</sub>
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<ReferenceList><Reference><Citation>J Cell Biol. 1977 Jan;72(1):174-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12184</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 2008 Dec 9;47(49):13016-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19049291</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Appl Microbiol Biotechnol. 2009 Mar;82(3):513-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19099300</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eukaryot Cell. 2010 Dec;9(12):1825-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20870876</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Expert Opin Ther Pat. 2011 Feb;21(2):167-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21204724</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biotechnol. 2012 Jul;51(3):212-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21979823</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Plant Pathol. 2012 May;13(4):329-37</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22013895</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chem Biol Drug Des. 2013 Jan;81(1):136-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23253135</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2014 Feb 20;9(2):e89336</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24586697</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioorg Med Chem. 2014 Aug 1;22(15):4285-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24916028</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioorg Med Chem. 2014 Aug 1;22(15):3922-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25002231</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Microbiol. 2016 May 20;7:762</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27242773</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2018 May 8;8(1):7161</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29740047</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Environ Manage. 2019 Mar 1;233:523-529</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30594117</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Talanta. 2019 Apr 1;195:55-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30625581</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Agric Food Chem. 2019 Feb 20;67(7):1823-1830</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30677302</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2019 Jan 31;9(1):1064</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30705359</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Anal Chem. 2019 May 7;91(9):5573-5581</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30938150</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 1981 Jun 9;20(12):3629-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7020758</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biophys J. 1997 Mar;72(3):1357-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9138581</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
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Novel Peptide-Based Inhibitors for Microtubule Polymerization in Phytophthora capsici.

Novel Peptide-Based Inhibitors for Microtubule Polymerization in Phytophthora capsici.

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